Preheat the oven to 350°F and line a loaf pan with parchment paper. In a large bowl, whisk together the flour, sugar, baking powder, baking soda, and salt.
In a separate bowl, mix the sourdough discard, melted butter, eggs, sour cream, milk, vanilla extract, lemon zest, and lemon juice until smooth.
Pour the wet ingredients into the dry ingredients and stir gently until just combined. Do not overmix.
Transfer the batter to the prepared loaf pan and smooth the top. Bake for 50 to 60 minutes, until the loaf is set and a toothpick inserted in the center comes out clean.
Let the bread cool in the pan for 10 minutes, then transfer to a wire rack to cool completely.